Alzheimer's disease drug screening:

Alzheimer’s disease (AD), the leading cause of dementia in the elderly, is a complex neurodegenerative disorder resulting in a progressive decline in cognitive functions. The search for novel anti-AD drugs from a large numbers of synthesized or natural compounds requires rapid and effective screening models for the biological evaluation. Because of their cost-effectiveness and gene similarity with human, zebrafish models have drawn more and more attention in anti-AD drug discovery.

Hunter has developed new AD models using larval zebrafish for the biological evaluation of anti-AD compounds. The AD model could be induced by AlCl3, scopolamine or Aβ. Drug effect could be evaluated based on quantitative analysis of motility and response efficacy, acetylcholine esterase (AChE) activity and tau protein phosphorylation could also be tested if needed.