Why use the zebrafish in research?
The zebrafish is small and robust.
They are cheaper to maintain than mice.
Break of daylight triggers mating in zebrafish (many other fish only lay eggs in the dark).
Zebrafish produce hundreds of offspring at weekly intervals providing scientists with an ample supply of embryos to study.
They grow at an extremely fast rate, developing as much in a day as a human embryo develops in one month. Zebrafish embryos are nearly transparent which allows researchers to easily examine the development of internal structures. Every blood vessel in a living zebrafish embryo can be seen using just a low-power microscope.
As zebrafish eggs are fertilised and develop outside the mother’s body it is an ideal model organism for studying early development.
Zebrafish have a similar genetic structure to humans. They share 70 per cent of genes with us.
84 per cent of genes known to be associated with human disease have a zebrafish counterpart.
As a vertebrate, the zebrafish has the same major organs and tissues as humans. Their muscle, blood, kidney and eyes share many features with human systems.
Zebrafish have the unique ability to repair heart muscle. For example, if part of their heart is removed they can grow it back in a matter of weeks. Scientists are working to find out the specific factors involved in this process to see if this will help us to develop ways of repairing the heart in humans with heart failure or who have suffered heart attacks.
The zebrafish genome has been fully sequenced to a very high quality. This has enabled scientists to create mutations? in more than 14,000 genes to study their function.